The Morphology Study of Sleeping Pill Microcrystal using Microcrystalline Technique

Abstract

The objectives of this research were to study the morphology of sleeping pill crystal by microcrystalline technique, to study the optimum reagent concentration and preparation time and to compare the morphology difference of the tested sleeping pills. The crystal morphology of 6 different sleeping pills; Alprazolam, Amitriptyline, Clorazepate, Circadin, Lorazepam and Zolpidem was analyzed while 2 types of reagent; sodium carbonate (Na₂CO₃) and potassium iodide (KI) were examined. From the study, it was found that the applied concentrations of sodium carbonate are 1%, 5% and 10%, while the optimum concentration is 1%. Alprazolam showed a tuft crystalline nature. Amitriptyline was with the shaped of dendrites. Clorazepate was spherical shape with small drop-like crystal. Circadin demonstrated a stem-like tree shape with tuft at the tip. Lorazepam was a small fan-shaped connection. Zolpidem is bundle sheaf shape with anisotropic optical properties. Potassium iodide concentrations of 1%, 3% and 5% were prepared. The optimum concentration was different for each sample resulting in an individual microcrystal morphology. Alprazolam was a clear, tiny square crystal mixed with rounded-edge square crystal. Amitriptyline was a transparent hexagonal crystal whereas Clorazepate is a drop-like spherical crystal. Circadin crystal revealed a rectangular shape. Lorazepam was a triangular crystal with a tail and Zolpidem was a square crystal. The optical properties of Alprazolam, Amitriptyline and Lorazepam were isotropic, non-color and no light reflection. Therefore, the preliminary examination of drugs or other suspected substances using microcrystalline technique should be further developed for more information and database.