Rapid detection of pathogenic bacteria with Superparamagnetic Iron-oxide Nanoparticles (SPIONs) using highly sensitive Magneto-impedance Sensor: A Preliminary Study
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Abstract
Recent progress in the detection of ultra-small magnetic fields down to nano-Tesla level at room temperature and without magnetic shielding has shown potential applications in magnetic marking, labeling, and detecting for target biological entities such as viruses, genes, proteins, and bacteria. Herein, we present the detection of stray magnetic fields of superparamagnetic iron-oxide nanoparticles (SPIONs) in liquid medium (Trypticase Soy broth, TSB) and SPIONs bound to test bacteria (Escherichia coli). The stray magnetic fields of SPIONs captured E. coli, and that of the control samples were measured using a highly sensitive magneto-impedance (MI) sensor. The output voltage of MI-sensor of SPIONs-captured E. coli sample was significantly lower than the control samples. Homogenizing samples prior detection and the introduction of the external static magnetic field, Hext, of ~ 0.2 mT to the samples showed remarkable enhancement of magnetic signals. The preliminary study of SPIONs capturedE. coli in dairy beverages has been performed. This simple and versatile technique for detecting magnetic nanoparticles can be further developed for a portable magnetic biosensor.
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